【摘要】 用荧光显微成像测量了两种阿尔茨海默症(Alzheimer’s disease,AD)模型细胞,即swe型N2a细胞和Δ9/swe型N2a细胞中活性氧的水平。结果发现,培养液中适当浓度的壳寡糖降低了两种模型细胞中的活性氧水平,这一抑制作用随壳寡糖浓度的变化而变化。壳寡糖对两种模型细胞作用存在差别,提示壳寡糖抑制AD模型细胞内活性氧可能有不同的途径。更多还原

【Abstract】 The levels of reactive oxygen species(ROS) in two AD(Alzheimer’s Disease) model cells,i.e.,swe N2a cell and Δ9/swe N2a cell,were compared by using fluorescence microscopic imaging.Chitooligosaccharide of proper concentration in culture medium suppressed the ROS level in the two AD model cells.The ROS suppressing function was variable with change of chitooligosaccharide concentration and was different for the two AD models.The difference suggests that chitooligosaccharide suppresses ROS level in AD model cells through different pathways.更多还原