【摘要】 STAT3是信号转导与转录活化蛋白(STAT)家族的一个重要成员,也是一个可以被多种调控细胞增殖、分化、发育、存活和炎症的细胞因子、生长因子及肿瘤蛋白所激活的关键信号转导蛋白。在多种肿瘤细胞、细胞性状转化过程和肿瘤形成过程中可以检测到组成性激活的STAT3。我们从STAT3在肿瘤细胞中组成性激活的机制、STAT3作为转录因子对肿瘤细胞调控的机制等方面对STAT3在肿瘤发生中的作用进行简要综述。更多还原

【Abstract】 STAT3 is an important member of the signal transducer and activator of transcription(STAT) family of transcription factors.It is a key signal transduction protein activated by numerous cytokines, growth factors and oncoproteins that controls cell proliferation, differention, development, survival and inflammation.Constitutive activation of STAT3 has been found frequently in a wide variety of human tumors and celluar transformation and tumor formation.In this article, the effects of STAT3 on the tumorigenesis were reviewed.For instance, the mechanism of constitutive activation of STAT3 in tumor cells, the mechanism of STAT3’s regulation to tumor cells as a transcription factor and so on.更多还原