【摘要】 通过熔融挤出系统(Melted extrusion manufacturing,MEM)制备聚己内酯(Poly(-εcaprolactone),PCL)三维多孔骨组织工程支架,采用NaOH溶液对多孔支架进行表面改性处理,将表面改性后的支架于真空下经CaCl2和K2HPO4进行晶核化预处理,然后对该支架进行矿化性能研究。结果表明:NaOH表面改性处理在样品表面上引入了羧基,多孔支架表面的亲水性得到改善,表面接触角由改性前的70.1°降为改性后的26.52°;经晶核处理后的样品在c-SBF溶液中的矿化研究表明,24 h内就可以在样品表面生成一层致密的类骨磷灰石层。更多还原

【Abstract】 In the present study,porous PCL(poly(ε-caprolactone)) scaffolds were prepared through a melted extrusion manufacturing(MEM) machine,and carboxylate groups were formed on the surfaces of specimen by hydrolyzation with NaOH aqueous solutions.Apatite precursor was introduced on the surfaces of specimens with CaCl2 and K2HPO4 under vacuum condition,and mineralization study was applied to these specimens.The results showed that the hydrophilicity of PCL surface was improved with the introduction of carboxylate groups,and the contact angle of surface was decreased to 26.52°.A dense and uniform bone-like layer was confirmed to be formed on the surface of Ca-P treated specimens after mineralizing for less than 24 h in SBF by SEM and EDAX.更多还原