【摘要】 采用自乳化溶剂蒸发法制备负载VE醋酸酯(VEA)的聚乙二醇单甲醚-b-聚乳酸两亲性二嵌段共聚物纳米分散液(PMV)。采用紫外分光光度计和激光粒度仪等方法测定PMV纳米粒的载药量、粒径和粒径分布以及VEA的包封率,并对PMV的体外释放进行了初步研究。实验结果表明,PMV纳米粒的平均粒径小于300 nm,制备方法、有机溶剂的性质、VEA的投药量、分散体系的浓度等对PMV的影响较大;PMV的体外释放无突释现象,14h的累积释放量大于79%。本研究为开发VEA新型给药系统提供了实验依据。更多还原

【Abstract】 VE acetate-loaded methoxy poly(ethylene glycol)-b-poly(lactic acid) amphiphilic diblock copolymer nano-dispersion(PMV) was prepared by self-emulsification/solvent evaporation method.The drug-loaded amount,size distribution of PMV nanoparticles,and entrapment efficiency of VE acetate(VEA) were determined by UV and laser particle analyzer.Drug release in vitro was primarily investigated by UV.The results indicate that the size of PMV nanoparticles is less than 300 nm and PMV is largely influenced by preparation methods,property of solvents,VEA-fed amount,and the concentration of dispersion.The initial burst release is not observed and the accumulated release is more than 79% after 14 h.This study develops a new formulation for VEA and provides an experimental basis for the novel drug delivery systems of VEA.更多还原