【摘要】 对动脉粥样硬化(AS)大鼠的主动脉进行血管生物力学研究,以了解AS所导致的主动脉血管生物力学特性。建立大鼠AS动物模型,测量离体主动脉血管零应力状态展开角,进行血管生物力学载荷试验,以获得压力-应力关系的数据,对AS组大鼠主动脉电镜标本,作组织纤维含量百分率测定,分析力学参数与组织纤维含量的关系。研究结果显示(1)AS大鼠的零状态展开角明显小于对照组(87.74°±9.67°vs 196.03°±27.76°,P<0.001);(2)主动脉在长轴、短轴方向的应变物质常数α0、α1、α2及b0、b1、b2的绝对值均明显低于对照组(P<0.05～0.001);(3)AS组大鼠主动脉纤维组织百分率与物质常数a值及b值各参数之间具有良好的相关性(r值在-0.7523～-0.8423之间,P<0.001)。本研究提示AS主动脉病理重构与力学性重构之间存在密切的联系。更多还原

【Abstract】 To understand the mechanical properties of aortic artery of atherosclerosis(AS),the aortic artery of rat with AS was studied by mechanical test.Wistar rats were used for establishing the model.The mechanical measurements of opening angle in zero-stress state and the vessel loading test were conducted on the isolated aortic arteries of AS rats.Data on the stress-strain of aortic artery were obtained.Determination of percentage of collagen content was made with the use of electron microscope.The relationship between mechanical measurements and collagen concentration was evaluated.The opening angle in the group of AS was significantly smaller than that in control(87.74°±9.67° vs 196.03°±27.76°,P<0.001).Significant decrease of material constants(α0,α1,α2,b0,b1,b2) in both long axis and radial axis was observed in AS group(campared with control,P<0.05～0.001).Close relationship between the mechanical constants and the percentage of elastin and collagen content was observed(r=-0.7523 to-0.8423,P<0.001). In conclusion,mechanical remodeling in aortic artery of AS might be related with histological remodeling.更多还原