【摘要】 代谢型GABAB受体是C族蛋白偶联受体中的特殊的异源二聚体成员,由GABAB1亚基和GABAB2亚基组成。每个亚基在受体的激活过程中具有各自不同的功效。初步研究发现GABAB受体的活性下调方式如失敏和内化并不遵从经典的路径。近期的研究还发现GABAB受体新的生理功能,GABAB1亚基的不同亚型体在认知学习中具有重要的作用。更多还原

【Abstract】 GABAB receptor is an atypical member of class-C G protein coupled receptor family which is heterodimerized by GABAB1 and GABAB2 subunits. The two subunits convey specific and different components during activation. Pilot study on down regulation mechanism of GABAB receptor such as desensitization and internalization indicated that this receptor did not obey the classical way. Recent studies have shed light on the roles of GABAB receptors in cognition process and GABAB1 isoforms contribute differentially to GABAB receptor-mediated cognitive processes.更多还原