【摘要】 阿尔茨海默病(Alzheimer’s disease,AD)是一种重要的痴呆类型,AD是一种变性痴呆,特点是65岁以上的老年人易患.。AD起病侵袭,主要表现是记忆力下降,神经生化改变参与其中,许多神经递质缺陷。AD的病因至今未明。丝裂原激活的蛋白激酶(Mitogen一activated protein kinase,MAPK)和蛋白激酶C(protein kinase C,PKC)信号传导通路在细胞增殖、分化、生长、凋亡和恶性转化中起重要作用。本文综述了信号传导通路在阿尔茨海默病中的作用。更多还原

【Abstract】 Alzheimer’s disease (AD) is an important kind of dementia, AD is a primary degenerative dementia, and its characteristic is attacking at age of over 65.Its progress is slow,and main manifestions are decreasing in memory, and in neurochemistry, often deficits in many neurotransmitters.The etiology of Alzheimer’s disease is unknown up to now. Signal transduction of mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) play an important role in cell proliferation, differentiation, growth, apoptosis and malignant transformation. The roles of signal transduction mechanisms in Alzheimer’s disease was reviewed in this study.更多还原