【摘要】 DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误,保证基因组的稳定性和完整性。错配修复系统缺陷可能导致遗传物质发生突变,引发恶性肿瘤。肿瘤患者经常表现出染色体不稳定,具体表现为微卫星不稳定性和杂合性缺失。本文就DNA错配修复、染色体不稳定和肿瘤之间的联系予以综述。更多还原

【Abstract】 DNA mismatch repair system could recognize and repair mistakes in process of DNA replication, guard stability and integrality of genome.The defective mismatch repair system may result in mutations of genome and cause tumors.The tumor patients usually show chromosome instability:microsatellite instability(MSI) and loss of heterozygosity(LOH).This paper reviewed the relationship between DNA mismatch repair, chromosome instability and cancer.更多还原