【摘要】 以可溶性淀粉原料,K2S2O8-NaHSO3为引发体系,N,N′-亚甲基双丙烯酰胺为交联剂,合成淀粉/N,N′-亚甲基双丙烯酰胺交联微球,采用人工肠液对所得微球进行体外降解,用FT-IR对其结构进行表征,用XRD、TGA对其物性进行分析,用SEM观察了微球及降解8h的产物。结果表明,使用该方法制备的交联微球球型元整,表面粗糙多孔,粒径约25μm,与可溶性淀粉相比结晶度降低,热稳定性提高。降解实验表明,可溶性淀粉在人工肠液中3h内基本降解,而微球经8h降解,仍可稳定维持其交联结构,其降解率为36.58%。因此有望将其作为靶向制剂的药物载体在鼻腔给药系统、动脉栓塞技术、放射性治疗、免疫分析等领域得到广泛应用。更多还原

【Abstract】 The starch/N,N’-methylene-bis-acrylamide crosslinked microsphere was synthesized from soluble starch, initiated by potassium persulphate -sodium bisulfite, used N,N′ -methylene -bis -acrylamide as the crosslinking agent. Microspheres were degraded by using artificial intestinal juice in vitro and characterized by FT-IR spectroscopy, X-ray diffraction (XRD), granularity analyzer and thermo gravimetric analysis(TGA). Microspheres and the products of degraded eight hours were observed by SEM. Experimental results indicate that microspheres synthesized by using this method are round, rough and the particle size is about 25 μm. Compared with soluble starch, crystallinity degree of microspheres are lower, thermal stability are improving. The degradation experiments show, soluble starch are degraded in three hours by using artificial intestinal juice, but when 8 hours have pasted, microspheres can maintain their crosslinking structure stable, the degradation rate are 36.58%. It is hopefull that can be widely used as drug carrier system in the field of nasal drug delivery system, artery embolism technology, radioactive therapy and immunoassay.更多还原