【摘要】 目的探讨急性有机磷农药中毒(AOPP)病人血清胆碱酯酶(ChE)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)活性变化及其意义。方法检测38例重度AOPP病人入院第1、3、7天血清ChE、CK-MB和LDH活性,以10例健康成人作为对照。结果与对照组比较,AOPP组病人血清ChE降低,CK-MB、LDH升高,差异有显著性(F=142.515~513.542,q=4.505~42.764,P<0.05、0.01);与第1天比较,入院第3天、第7天AOPP组病人血清ChE升高,CK-MB、LDH降低,差异有显著性(q=17.665~45.655,P<0.05、0.01)。随治疗进展,血清ChE、CK-MB和LDH活性呈逐渐恢复趋势。结论血清ChE水平不能作为临床评价有机磷农药中毒程度的有效指标,而CK-MB和LDH可作为有机磷农药中毒程度、病情和预后的判断指标。更多还原

【Abstract】 Objective To investigate the changes of enzymatic activity of serum ChE,CK-MB and LDH in patients with AOPP and their clinical significance. Methods The activity of serum ChE,CK-MB and LDH was determined in 38 patients with AOPP on day 1,3 and 7 after admission.Ten healthy people served as normal controls. Results Compared with the control group,the serum concentration of ChE was significantly reduced,and that of CK-MB and LDH were significantly increased in patients with AOPP(F=142.515-513.542;q=4.505-42.764;P<0.05,0.01).Within the patient group,the serum ChE was significantly higher,and that of CK-MB and LDH were lower on day 3 and day 7 than on day 1(q=17.665-45.655;P<0.05,0.01).After treatment,the serum concentration of three enzymes gradually became normal. Conclusion Serum level of ChE is not an effective parameter for evaluating the degree of poinsoning of AOPP,while CK-MB and LDH can be used to judge its and predict its prognosis.更多还原