【摘要】 目的探讨阿托伐他汀对高血压早期肾损害的影响。方法将59例经服用氨氯地平、倍他乐克等药物血压降至正常值(≤18.4/12.0kPa)的高血压病人随机分成阿托伐他汀治疗组(n=29)和对照组(n=30),分别于治疗前和治疗后12周,检测尿微量清蛋白(MAu)、尿β2-微球蛋白(β2-MG)以及N-乙酰-β-D-氨基葡萄糖苷酶(NAG)。结果治疗组治疗后MAu、β2-MG、NAG较治疗前及对照组均降低,差异有显著性(t=2.731～12.831,t′=10.046、2.199,P<0.05、0.01)。结论阿托伐他汀可用于高血压早期肾损害的治疗。更多还原

【Abstract】 Objective To assess the effect of Atorvastatin on early renal damage in patients with essential hypertension(EH).MethodsFivty-nine EH patients,whose blood pressure were dropped to normal(≤18.4/12.0 kPa) after treated with Amlodipine and Betaloc,were divided into Atorvastatin-treated groups(29 cases) and control groups(30 cases).The urine β2-microglobulin(β2-MG),uric albumin(MAu) and n-acetyl-β-d-glucosaminidase(NAG) were detected 12 days before and after treatment.ResultsAfter therapy,the levels of β2-MG,MAu and NAG were significantly lower than that of the control and before treatment,the differencs were significant(t=2.731-12.831,t’=10.046,2.199;P<0.05,0.01).ConclusionAtorvastation can be used for early renal damage in patients with essential hypertension.更多还原