【摘要】 目的研究颅脑创伤病人的血清促肾上腺皮质激素(ACTH)、总皮质醇、皮质类固醇结合球蛋白(CBG)以及游离皮质醇状态,了解颅脑创伤后机体的内分泌反应以及相关激素的昼夜节律变化。方法采用化学发光及放射免疫分析法对32例颅脑创伤病人血清ACTH、总皮质醇、CBG水平进行测定,并通过计算获得游离皮质醇水平,进行横断面分析研究。结果颅脑创伤病人血清ACTH、总皮质醇、CBG多处于正常水平,且ACTH、总皮质醇存在昼夜节律变化,而CBG、游离皮质醇无昼夜节律变化。结论颅脑创伤后,多数病人血清ACTH、总皮质醇、CBG及游离皮质醇水平位于正常参考范围,垂体-肾上腺功能多保持完整,ACTH及总皮质醇存在昼夜节律变化,但有约50%的病人可出现不同类型皮质醇分泌异常。更多还原

【Abstract】 Objective To investigate serum ACTH,total cortisol,corticosteroid-binding-globulin(CBG) and free cortisol and their circadian changes in craniocerebral trauma. Methods Serum ACTH,total cortisol,and CBG in 32 patients were measured by chemical illuminate and radioimmunoassay,free cortisol was calculated by Coolens equation and analyzed by cross-sectional study. Results The ACTH,total cortisol,CBG and free cortisol in the patients were mostly within normal range;circadian changes of ACTH and total cortisol existed,but CBG and free cortisol were not involved. Conclusion Following craniocerebral trauma,the levels of ACTH,total cortisol,CBG and free cortisol in most patients remain within normal scope;pituitary-adrenal function remains complete;ACTH and total cortisol show day-night rhythm changes,while about 50% of patients may present different-type abnormal cortisol secretion.更多还原