【摘要】 p73是肿瘤抑制基因p53家族新成员,它表达多种具有不同功能特点的蛋白质异构体.综述p73蛋白的分子结构、功能以及在血液系统恶性肿瘤中的生物学行为,旨在探索p73与血液系统恶性肿瘤的关系,为血液系统恶性肿瘤的诊断、治疗及预后提供理论依据.更多还原

【Abstract】 The p73 gene,a new member of tumor suppressor gene p53 family,gives rise to multiple protein isoforms with different functions. The structure and functions of p73 proteins as well as biological role in hematological malignancies are reviewed in order to explore correlation between p73 and hematological malignancies,thus rendering a rationale for diagnosis,therapy and prognosis of hematological malignancies.更多还原