【摘要】 内质网是细胞内蛋白质合成折叠、Ca2+储存和脂质合成的重要部位。内质网稳态的破坏将导致大量错误或者未折叠蛋白质在内质网中的聚集,通过相应的信号通路,引起一系列的细胞反应,即内质网应激。内质网应激参与心脏的发育和多种心脏疾病的发生发展,包括心肌缺血和再灌注损伤、心肌病、心力衰竭等。内质网应激可能是研究心血管疾病发病机制和防治措施的新靶点。更多还原

【Abstract】 Endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis and folding of proteins,calcium storage and synthesis of lipid. Perturbations of ER functional homeostasis result in accumulation of misfolded or unfolded protein in ER,which induces a series of cellular responses(ER stress) through proportional signaling pathway. It is reported that ER stress contributes to development of diseases of heart,including myocardial ischemia-reperfusion injury,cardiomyopathy and heart failure,et al. ER stress might be a novel therapeutic target in heart diseases.更多还原