【摘要】 目的:鉴定六味地黄丸中的化学成分和代谢成分。方法:采用超快液相色谱梯度洗脱,飞行时间质谱正负离子同时检测。结果:在六味地黄提取物中鉴定了40种化学成分,在大鼠血中鉴定了6种原型药物和9种代谢产物,并推断了以上产物的代谢途径。结论:UFLC-ESI-IT-TOF方法适合于复杂中成药样品的分析,有助于全面了解六味地黄丸中的化学成分和代谢成分。更多还原

【Abstract】 Objective: To identify the chemical and metabolic components. Method: UFLC gradient elution with TOF detection in positive and negative mode. Result: 40 chemical components were identified in Liuwei Dihuang extract. 6 original component and 9 metabolites were identified in rat serum. The proposed metabolic pathway was given. Conclusion: UFLC-ESI-IT-TOF was a powerful method in the analysis of complicated TCM samples. It helps the comprehensive understanding of the chemical and metabolic components of Liuwei Dihuang Pills.更多还原