【摘要】 目的探讨人颈动脉粥样硬化斑块内幽门螺杆菌-细胞毒素相关蛋白A(Hp-CagA)-IgG抗体的表达水平与颈动脉粥样硬化性脑梗死之间的关系。方法选择24例因颈动脉粥样硬化狭窄行颈动脉内膜切除术且合并Hp-CagA阳性菌株感染的患者,分为有缺血性脑卒中事件组(16例)和无缺血性脑卒中事件组(8例),采用酶联免疫吸附试验检测颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度。结果有缺血性脑卒中事件组的颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度显著高于无缺血性脑卒中事件组(P<0.05)。结论颈动脉粥样硬化斑块内Hp-CagA-IgG抗体表达的增高可能通过影响斑块的稳定性,导致颈动脉粥样硬化性脑梗死的发生。更多还原

【Abstract】 Objective To explore the association between Helicobacter pylori-cytotoxin-associated protein A-antibody IgG(Hp-CagA-IgG)in carotid atherosclerotic plaque and carotid atherosclerotic cerebral infarction.Methods A total of 24 patients with carotid atherosclerotic sclerostenosis undergoing carotid endarterectomy complicated with Hp-CagA positive strain infection were selected in this study.The patients were divided into two groups:with ischemic stroke incident(n=16)and without ischemic stroke incident(n=8).The presence of Hp-CagA-IgG antibody in the carotid atherosclerotic plaques was performed by enzyme linked immunosorbent assay(ELISA).Results The level of Hp-CagA-IgG antibody in the carotid atherosclerotic plaque in group with ischemic stroke incident was significantly higher than that in group without ischemic stroke incident(P<0.05).Conclusion High expression of Hp-CagA-IgG antibody in carotid atherosclerotic plaque may affect carotid atherosclerotic plaque stability,which may subsequently cause carotid atherosclerotic cerebral infarction.更多还原