【摘要】 生长调节致癌基因-1(GRO-1)是CXC趋化因子的一种,GRO-1与其受体CXCR2结合后,参与机体的多种病理生理过程,包括炎症、感染、创伤愈合和肿瘤发生。其在恶性肿瘤演进中所起的作用是多方面的,它通过直接促进肿瘤生长、转移以及通过促进肿瘤血管形成、白细胞浸润,共同促进肿瘤的发生发展。因此,GRO-1可能可以作为肿瘤的治疗靶点和诊断标志物。更多还原

【Abstract】 Growth-regulated oncogene-1 (GRO-1) is a member of the CXC chemokines.GRO-1 binds to CXC chemokine receptor 2 (CXCR2) and play a functional role in many patho-physiological conditions,including inflammation,infection,wound healing,and tumorigenesis.The role of GRO-1 in malignant tumors is complex:GRO-1 may participate in tumor growth and metastasis by promoting tumor cell proliferation,migration,neovascularization or neutrophil infiltration in tumor tissue.Therefore,GRO-1 may be a therapeutic target as well as a diagnostic marker in cancers.更多还原