【摘要】 目的 检测和比较分析WHBE兔、日本大耳白兔、新西兰白兔的血液流变学及凝血功能指标，揭示WHBE兔血液流变学和凝血系统在实验兔中特性。方法 选择WHBE兔，日本大耳白兔，新西兰兔各40只，雌雄各半，兔耳中央动脉采血抗凝血，测定全血粘度、血浆粘度等16项血液流变学及凝血功能指标。结果 (1)性别因素对WHBE兔的红细胞压积、血沉、血沉方程K值、红细胞计数5项血液流变学指标存在着显著差异(P<0.05,P<0.01)，而对凝血功能无明显影响(P>0.05);(2)与WHBE兔比，WHBE兔血液流变学指标与日本大耳白兔无明显差异(P>0.05)，但雌性WHBE兔PT、PT/R、PTINR明显高于雌性日本大耳白兔(P<0.05),PT%显著低于雌性日本大耳白兔(P<0.05);而雄性新西兰白兔全血粘度低切、Fbg和TT明显低于雄性WHBE兔(P<0.05)，且红细胞压积显著高于雄性WHBE兔，另外，雌性新西兰白兔全血粘度高切、中切、低切、毛细管血浆粘度、全血还原粘度低切、高切、红细胞变形指数、红细胞电泳指数和卡松粘度、PT%均显著低于雌性WHBE兔(P<0.05,P<0.01)，而红细胞压积、血沉方程K值、PT、PT/R、PTINR均显著高于雌性WHBE兔(P<0.01);(3)WHBE兔的血液流变学及凝血指标与人类较为接近。结论 血液流变学特性和凝血功能的测定，可为WHBE兔在生物医学领域的应用提供参考数据。更多还原

【Abstract】 Objective To determine and comparative analysis of hemorheological parameters and blood coagulation function in WHBE rabbits, Japanese White rabbits and New Zealand White rabbits, and further to reveal on hemorrheological and blood coagualtion system characteristics of WHBE rabbits.Methods Fourty in each of WHBE rabbits, Japanese White rabbits and New Zealand White rabbits, half male and female, the anticoagulant blood samples from the central artery of ear, and then hemorrheological parameters and blood coagulation function were determined by automatic hemorheology analyzer and CA-500 automatic blood coagulation analyzer, respectively. Results(1) Gender factor has significant influences on hematocrit, the erythrocyte sedimentation rate, K value of erythrocyte sedimentation rate equation and erythrocyte accounts in WHBE rabbits(P<0.05, P<0.01),but has no significant influence to blood coagulation of WHBE rabbits(P>0.05);(2) Compared with WHBE rabbits, the hemorheological parameters of WHBE rabbits have no significant difference to Japanese White rabbits(P>0.05), but PT,PT/R, PTINR of female WHBE rabbits were obvious higher than those of female Japanese White rabbits(P<0.05), and PT% was lower than that of female Japanese White rabbits(P<0.05); while whole blood viscosity at low shear rate, Fbg and TT of male WHBE rabbits were higher than those of male New Zealand White rabbits(P<0.05), hematocrit was obviously lower in WHBE rabbit than those of New Zealand White rabbits(P<0.05), moreover, the whole blood viscosity, capillary plasma viscosity, blood reduced viscosity at low and high shear rate, erythrocyte deformation index, erythrocyte electrophoresis index, casson viscosity and PT% were higher in female WHBE rabbits than those of female new Zealand White rabbits(P<0.05, P<0.01), while hermatocrit, K value of erythrocyte sedimentation rate equation,PT, PT/R and PTINR was significant lower than those of female New Zealand White rabbits(P<0.01);(3)The hemorrheological parameters and blood coagulation function in WHBE rabbits were similar to those of human being. Conclusion Determination of hemorheological parameters and blood coagulation function in WHBE rabbit may be providing basic reference to biomedical research.更多还原