【摘要】 目的 通过在SD大鼠建立动物模型为袖带胃减容手术基础研究提供平台。方法 实验组SD大鼠20只进行袖带胃减容手术，对照组SD大鼠10只进行剖腹探查，术前、术后第一天及术后16周内每隔两周进行体重测量。结果 对照组10只大鼠均存活，实验组大鼠存活13只。对照组大鼠在术后体重增长明显，实验组大鼠体重在术后2周恢复术前水平，体重增长明显但较对照组慢(P<0.01)。实验组术后胃扩张明显术后长径(2.02±0.20 cm vs 3.02±0.52 cm, P<0.01;术后短径0.91±0.10 cm vs 1.58±0.35 cm, P<0.01)。结论 在SD大鼠建立袖带胃减容手术模型是可行的，可通过该模型进一步研究袖带胃减容手术的减重机制及体重反弹等相关机制。更多还原

【Abstract】 Objiective To establish an animal model for sleeve gastrectomy in SD rat.Methods Twenty male SD rat were operated with sleeve gastrectomy. Ten male SD rat were operated with laparotomy. The weight of the rats were determined before operation, 1st day post operation and on Fortnightly basis for 16 weeks. Results All rats remained alive in the control group, 13 rats remained alive in the SG group. In the control group, weight gain was achieved obviously after operation,whereas in the SG group, weight gain was achieved until the 2th week. In the SG group, weight gain was significantly lower than in the control group. Gastric dilatation were observed obviously in the SG group(2.02 ± 0.20 vs 3.02 ± 0.52, P<0.01; 0.91 ± 0.10 vs 1.58 ± 0.35, P<0.01). Conclusion The SG experimental model established on SD rat was reliable,and it may be used for study the mechanisms of sleeve gastrectomy.更多还原