【摘要】 目的:通过检测婴幼儿血管性疾病外周静脉血(简称外周血)、瘤内血中的碱性成纤维细胞生长因子(bFGF)的表达,探讨对血管瘤和血管畸形进行鉴别诊断的可能。方法:应用酶联免疫吸附法(ELISA)检测资料完整的14例静脉畸形患儿瘤内血和外周血bFGF,检测49例血管畸形患儿、32例血管瘤患儿和23例对照婴幼儿外周血清中bFGF的浓度,采用SPSS11.5软件包对数据进行t检验和方差分析。结果:静脉畸形瘤内、外周血清中bFGF浓度有显著差异(P<0.05),瘤内血清bFGF浓度高于外周血清;血管瘤、血管畸形和对照组外周血清bFGF浓度无统计学差异(P>0.05)。结论:静脉畸形患儿瘤内血清的bFGF浓度高于外周血清,检测外周血bFGF,不能鉴别血管瘤和血管畸形。更多还原

【Abstract】 PURPOSE: To investigate the expression of basic fibroblast growth factor (bFGF) in infant’s peripheral blood and tumor blood of vascular malformation and peripheral venous blood of hemangioma, and the possibility to differentiate hemangioma from vascular malformations by detecting bFGF level in peripheral blood. METHODS: The level of bFGF in peripheral blood (49 vascular malformations ,32 hemangioma cases and 23 normal cases) and tumor blood (14 venous malformations) of infants was measured by ELISA.SPSS11.5 software package was used to analyze the data and student’s t test and ANOVA were used to determine the difference between different groups. RESULTS: The expression of bFGF in tumor blood from infants with venous malformations was significantly higher than that in peripheral blood (P<0.05); No significant difference of bFGF level in peripheral blood was found between hemangioma,vascular malformation and normal infants(P>0.05). CONCLUSIONS: The level of bFGF in tumor blood of from infants with venous malformation was higher than that in peripheral blood; Examination of bFGF in peripheral blood can not differentiate hemangioma from vascular malformations.更多还原