【摘要】 目的:研究多囊卵巢综合征(PCOS)患者的血清抗苗勒氏管激素(AMH)水平,并初步探讨其在PCOS中的诊断价值。方法:收集2006年6月至12月在我院妇产科就诊的47例PCOS患者(研究组)和年龄匹配的40例健康女性(对照组),应用酶联免疫吸附(ELISA)法检测血清AMH水平。结果:研究组的血清AMH水平明显高于对照组(9.85±4.93ng/mlvs7.13±3.02ng/ml,P=0.002)。血清AMH的曲线下面积在总体人群为0.664(P=0.008),以血清AMH8ng/ml为相对最佳的诊断界值,敏感度为61.7%,特异度为70.0%。结论:PCOS患者的血清AMH水平明显增高,血清AMH测定对于PCOS的诊断效能较低。更多还原

【Abstract】 Objective:To detect the serum anti-Müllerian hormone(AMH)level of patients with polycystic ovary syndrome(PCOS),and to explore the diagnostic value of serum AMH measurement in PCOS.Methods:47 patients with PCOS and 40 healthy females were enrolled from June 2006 to December 2006 in the Second Affiliated Hospital of Sun Yat-sen University.Serum AMH levels were measured by enzyme linked immunosorbent assay(ELISA).Results:The mean serum AMH level in PCOS group was significantly higher than control group(9.85±4.93 ng/ml vs 7.13±3.02ng/ml,P=0.002),which is similar in adult PCOS patients and controls(10.64±5.47 ng/ml vs 7.01±2.43 ng/ml,P=0.005).No difference was found in serum AMH of adolescent PCOS patients and controls(8.95±4.18 ng/ml vs 7.26±3.58 ng/ml,P=0.168).The areas under the ROC curve for AMH in all PCOS population,adults and adolescents were 0.664(P=0.008),0.714(P=0.015),and 0.614(P=0.208),respectively.The best compromise between specificity(70.0%)and sensitivity(61.7%)was obtained with a cut-off value of 8 ng/ml.Conclusions:Serum AMH level was elevated in patients with PCOS.Serum AMH measurement offers a relatively poor sensitivity of 61.7% and a specificity of 70% with a cut off value at 8 ng/ml,suggesting the diagnostic value of AMH was limited.更多还原