【摘要】 目的:探讨益母草注射液在阴道分娩中预防产后出血和促进子宫复旧的有效性和安全性。方法:进行多中心、随机、单盲、阳性药物对照研究。2007年4～8月,全国15家三级医院联合进行448例病例研究,其中益母草组(A组)150例;益母草联合缩宫素组(B组)149例;缩宫素组(C组)149例。观察产后各时段子宫复旧情况、产时和产后阴道流血情况、产前产后血红蛋白、红细胞数的差值及药物副反应。结果:①产时和产后6小时时段A组缩宫效果不如B、C组,以后各时段比较无差异。②产后各时段比较,产后12小时时段A组阴道流血量较B、C组少(P<0.05),其余时段阴道流血量差异无统计学意义。③3组产后24小时总出血量、产后出血发生率比较差异无统计学意义(P>0.05)。④各组产后红细胞数和血红蛋白值均都有不同程度的下降,但产前、产后的差值比较组间差异无统计学意义(P>0.05);各组产后24小时出血量≥500ml的患者中A组产前、产后红细胞和血红蛋白差值显著低于B、C组(P>0.05)。⑤本研究中各组均未发生副反应。结论:益母草有缓慢但持续的缩宫效果,和缩宫素联合应用效果更好,药物安全性良好。更多还原

【Abstract】 Objective:To evaluate the efficacy and safety of Motherwort injection for preventing postpartum hemorrhage and promoting uterine contraction after vaginal delivery.Methods:A multi-center randomized single blind and positive medicine controlled clinical trial was conducted.448 cases from 15 hospitals were randomly divided into three groups(group A: 150 cases with Motherwort,group B: 149 cases with Motherwort and oxytocin,group C: 149 cases with oxytocin) from Apr 2007 to Aug 2007.Uterine Contraction in different periods,the amount of vaginal bleeding before and after delivery,the differential value of hemoglobin(Hb) and red blood cell(RBC) before and after delivery,as well as the side effects were observed.Results:①The effect of uterine contraction was worse in group A than that in group B and C within 6 hours after vaginal delivery and there was no difference in the other periods.② The amounts of vaginal bleeding within 12 hours in group A were less than those in group B and C(P<0.05) and there was no obvious difference in the other periods.(P>0.05).③There was no obvious difference among these three groups when comparison with the amounts of hemorrhage within 24 hours after delivery and the incidence of postpartum hemorrhage(P>0.05).④ The values of RBC and Hb were decreased after delivery in three groups.There were no differential values before and after delivery.The differential value of RBC and Hb was lower in group A than group B and C in these patients whose vaginal bleeding amounts ≥500 ml within 24 hours after delivery.⑤ There were no side effects in these three groups.Conclusions:Motherwort injection is useful for preventing postpartum hemorrhage and promoting uterine contraction slowly but continuously.The effect of using Motherwort combined with oxytocin is better than Motherwort.The use of Motherwort is safe.更多还原