【摘要】 目的探讨IgG型抗内皮细胞抗体(IgG-AECA)在神经精神狼疮(NPSLE)发生、发展中的作用及机制。方法采用免疫荧光法检测102例系统性红斑狼疮(SLE)患者(活动期62例,其中NPSLE 27例,非NPSLE35例,缓解期40例)的IgG-AECA。结果IgG-AECA的阳性率在活动期、缓解期患者分别为56.5%、22.5%(P<0.05)。NPSLE者阳性率和滴度明显高于非NPSLE者(P<0.05)。NPSLE患者治疗前明显高于治疗后(P<0.05)。结论IgG-AECA在SLE发生中起重要作用,与病情活动密切相关;IgG-AECA可作为评估SLE系统损害、监测疾病活动性、制定合理治疗方案的指标。更多还原

【Abstract】 Objective To investigate the role of IgG-antiendothelial cell antibody(IgG-AECA)in the occurrence and development of neuropsychiatric systemic lupus(NPSLE) and its mechanism.Methods One hundred and two patients with SLE were enrolled in this study,62 cases(include 27 NPSLE and 35 non-NPSLE)of which were in active stage,and 40 cases were in remission stage.The serum level of IgG-AECA were detected by indirect immunofluorescence(IIF) technique.Results The IgG-AECA positive rate of patients in active stage and remission stage were respectively 56.5%and 22.5%(P<0.05).The positive rate and titer of IgG-AECA in the NPSLE patients were significantly higher that those in the non-NPSLE patients(P<0.05).The titer of IgG-AECA in the NPSLE patients decreased after the treatment(P<0.05).Conclusions IgG-AECA may play an important role in the occurrence of SLE,and be closely related to the disease activity.IgG-AECA can be used as a serum marker for evaluating organ lesions,adjusting disease activity and deciding rational therapy plan.更多还原