【摘要】 目的研究慢性鼻窦炎伴嗅觉障碍患者行功能性鼻内镜手术前后嗅觉功能的改变,探讨慢性鼻窦炎嗅觉功能与鼻内镜手术的关系,并用透射电镜观察手术对嗅区黏膜超微结构的影响,为临床治疗慢性鼻窦炎患者的嗅觉障碍提供理论依据。方法对慢性鼻窦炎伴嗅觉功能障碍患者行功能性鼻内镜手术,于术前及术后6个月观察嗅觉功能变化并切取嗅区黏膜于透射电镜下观察超微结构。结果术后嗅觉及嗅上皮的超微结构均有不同程度的改善,主观嗅觉改善率为97%;异常超微结构由术前的100%降为20%。结论炎症导致的嗅上皮细胞由表及里各层的超微结构异常与嗅觉功能减退有关。功能性鼻内镜手术改善通气功能后及黏膜炎性反应消除后,随着嗅上皮超微结构的恢复,嗅觉也会有不同程度的改善。更多还原

【Abstract】 Objective To explore the influences of olfactory area cilia before and after functional endoscopic sinus surgery for chronic sinusitis complicated with olfactory sensation disorders,and to provide a theoretical foundation for clinical treatment of chronic sinusitis.Methods Olfactory area membranes of the nasal septum were cut under endoscopy and observed by a transmission electron microscope.Results Olfactory sensation recovery rate was 98%,and ultra microstructure of the olfactory epithelium recovered to 80%.Conclusions Ultra-structure disorder of olfactory epithelium cells induced by inflammation has relations to disorder of olfactory sensation.With the recovery of the ultra-structure of the olfactory epithelium,olfactory sensation is improved.更多还原