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大剂量辛伐他汀短期治疗对急性冠脉综合征患者血浆高敏C-反应蛋白水平的影响
Effects of short-term treatment with simvastatin on plasma high sensitive C-reactive protein levels in patients with acute coronary syndrome
【摘要】 目的研究大剂量(40 mg/d)和常规剂量(20 mg/d)辛伐他汀治疗急性冠脉综合征(ACS)2周后,对患者血浆高敏C反应蛋白(hs-CRP)水平的影响。方法选取ACS患者86例,随机分为常规剂量组(n=43,辛伐他汀20 mg/d)和大剂量组(n=43,辛伐他汀40 mg/d),测定治疗前和治疗1、2周后患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)和hs-CRP水平。结果治疗2周后,常规剂量组和大剂量组TG和HDL-C变化不明显,TC和LDL-C均下降(P<0.05),大剂量组下降更为明显;hs-CRP水平亦呈下降趋势,大剂量组下降更为明显(P<0.01)。相关性分析显示,治疗后血浆hs-CRP浓度的变化与同期血脂(TC、LDL-C、HDL-C、TG)水平的变化无显著相关性。结论短期大剂量辛伐他汀治疗可以使血脂和hs-CRP水平显著下降,减少炎症反应,稳定动脉粥样硬化斑块。
【Abstract】 Objective To explore the effects of 2-week 20 mg/d and 40 mg/d simvastatin treatment on plasma levels of high sensitive-Creactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods 86 patients with ACS were randomly divided into the conventional dose simvastatin group(n=43,20 mg per day) and the high-dose simvastatin group(n=43,40 mg per day).Levels of total cholesterol(TC),triglycerides(TG),low density lipid cholesterol(LDL-C),high density lipid cholesterol(HDL-C) and hs-CRP of all patients were determined before,one week and two weeks after the treatment.Results Both TC and LDL-C were decreased in the two groups(P<0.05),but the TG and HDL-C levels were not significantly changed.The plasma hs-CRP level had a downward trend in the two groups.The hs-CRP level was more significantly decreased in the high-dose group than in the conventional dose group(P<0.01).Correlation analysis showed that reduction of plasma hs-CRP level was not related to changes of plasma lipid level. Conclusion High-dose simvastatin may significantly reduce serum lipid and plasma hs-CRP levels in ACS patients and has an anti-inflammatory therapeutic effect and may stabilize atherosclerotic plaques in the short term.
【Key words】 Simvastatin; Coronary syndrome,acute; High-sensitive Creactive protein;
- 【文献出处】 山东大学学报(医学版) ,Journal of Shandong University(Health Sciences) , 编辑部邮箱 ,2009年03期
- 【分类号】R541.4
- 【被引频次】3
- 【下载频次】53