【摘要】 目的:探讨淋巴结微转移对结直肠癌患者病理分期的影响。方法:对2003年3月至2008年10月间手术切除的60例结直肠癌患者的990枚淋巴结进行常规HE染色和CK20免疫组化检查,检测结直肠癌的淋巴结转移,并对结果进行统计学分析。结果:应用HE染色法淋巴结转移检出率27.2%(269/990),CK20免疫组化淋巴转移检测率为37.2%(368/990),两者差异有统计学意义(P<0.05)。99枚淋巴结检出有微转移,11例TNM分期提高,HE染色重新分期率为18.3%(11/60)。结论:CK20免疫组化的检测可以显著提高淋巴结转移的检出率,有助于更准确地进行结直肠癌的临床病理分期。更多还原

【Abstract】 Objective: To detect micrometastasis in regional lymph nodes and evaluate the significance of the new assessment of nodal status in determining pN staging of colorectal carcinoma.Methods: In addition to HE,IHC with Cytokeratin-20 was used to detect micrometastasis in 990 lymph nodes from 60 patients with colorectal carcinoma from Mar.2003 to Oct.2008.Results: The detection rate of HE staining was 27.2%(269/990),and the detection rate of IHC staining was 37.2%(368/990)(P<0.05).Lymph node micrometastasis was further detected in 99 nodes from 11 patients.The rate of second HE staging was 18.3%(11/60).Conclusion: IHC with Cytokeratin-20 can increase the detecting of lymph node metastasis and have a significant impact on the staging system of colorectal carcinoma.更多还原