【摘要】 目的探讨降钙素原(PCT)及白细胞介素6(IL-6)在重症急性胰腺炎患者中的变化及意义。方法68例SAP患者入选本研究,其中SAP伴胰腺感染组36例,SAP不伴胰腺感染组32例。应用双抗体夹心免疫发光法及酶联免疫吸附法分别测定所有患者不同时段血清PCT和IL-6含量。结果PCT和IL-6水平在SAP合并感染组急性期(1~3d)显著升高,经合理抗生素治疗后,其血清水平明显下降,但仍高于不伴感染组,对于PCT及IL-6持续升高不降者预后较差。结论PCT对重症急性胰腺炎患者是否合并感染具有早期诊断价值,并对其预后判断具有重要意义。更多还原

【Abstract】 Objective To evaluate the changes and clinical significance of serum procalcitonin and IL-6 levels in patients with severe acute pancreatitis.Methods Of the enrolled 68 SAP patients,36 ones developed infection and the other 32 ones did not develop infection.Serum PCT was determined by double antibody sandwich immunoluminescence,IL-6 was determined by ELISA in all patients.Results In acute stage(1～3d),serum PCT and IL-6 levels in SAP concurrent infection group were mcuh more higher than of control group,through reasonable antibiotics treatment,serum PCT and IL-6 levels descend dramatically but were higher than of control group.It suggested that prognosis was bad when serum PCT and IL-6 levels advanced continually.Conclusion The level of serum PCT may be useful to identify the SAP patients who develop infection,which is helpful to the prognosis of SAP.更多还原