【摘要】 目的探讨血清MMP-9、TIMP-1和TNF-α在系统性红斑狼疮(SLE)患者中的水平及临床意义。方法采用ELISA双抗夹心法测定血清MMP-9、TIMP-1和TNF-α水平。结果40例SLE患者血清MMP-9水平与对照组比较差异有统计学意义(P<0.01),血清TIMP-1水平与对照组比较差异有统计学意义(P<0.05),血清TNF-a水平在SLE患者和对照组之间差别无统计学意义。结论血清MMP-9、TIMP-1和TNF-α参与了SLE的发病机制。更多还原

【Abstract】 Objective To discussion the clinical significance and serum levels of MMP-9,TIMP-1 and TNF-α in patients with systemic lupus erythematosus(SLE).Methods The serum MMP-9,TIMP-1 and TNF-α were measured by sandwich ELISA in 40 patients with SLE and 30 healthy controls.Results The serum level of MMP-9 was significantlv higher in patients with SLE compared with those in healthy controls(P<0.01).The serum level of TIMP-1 was significantly higher in patients with SLE compared with those in healthy counrols(P<0.05).There was no significant differences of serum TNF-a level between patients with SLE and healthy controls.Conclusion MMP-9、TIMP-1 and TNF-α may be involved in the pathogenesis of SLE.更多还原