【摘要】 目的:研究归芪合剂联合缬沙坦对2型糖尿病(T2DM)大鼠肾脏功能的保护作用。方法:建立T2DM大鼠模型,给予归芪合剂联合缬沙坦灌胃治疗12周,测定大鼠空腹血糖(FBG)、血脂(TG)、总胆固醇(TC)、超氧化物歧化酶(SOD)、丙二醛(MDA)的水平;测定胰岛素敏感指数(ISI)、肾脏肥大指数(KW/BW)和肾皮质钠钾-ATP酶活性。结果:①与正常对照组比较,T2DM模型组大鼠FBG、TG、TC、MDA和KW/BW显著升高,SOD、ISI和肾皮质钠钾-ATP酶活性显著降低;②与T2DM模型组比较,治疗组大鼠FBG、TG、TC、MDA和KW/BW显著降低,SOD、ISI和肾皮质钠钾-ATP酶活性显著升高。结论:归芪合剂联合缬沙坦对T2DM大鼠肾脏功能具有明显保护作用,其机制可能与降低糖尿病大鼠血糖血脂,提高机体抗氧化应急能力和改善肾脏局部血循环有关。更多还原

【Abstract】 Objective:To investigate the protection of guiqi liquid & valsartan on the renal function in the type 2 diabetic rats.Methods: Male Wistar rats were developed a rat model of type 2 diabetes mellitus.The diabetes rats were received guiqi liquid & valsartan for 12 weeks.The following parameters were measured: fasting blood sugar(FBG),triglyceride(TG),total cholesterol(TC),KW/BW,insulin sensitivity index(ISI),superoxide dismutase(SOD),malondialdehyde(MDA) and sodium pump activity of renal cortex.Results: ①Compared to the controls,FBG,TG,TC,MDA level and KW/BW in the model rats were significant increase;SOD,ISI and sodium pump activity of renal cortex were significant decrease(P<0.01 or P<0.05);②Compared to model controls,TG,TC,MDA level and KW/BW in the treat group rats were significant decrease;SOD,ISI and sodium pump activity of renal cortex were significant increase(P<0.01 or P<0.05).Conclusion: Guiqi liquid & valsartan can defend renal function,it may be caused by the depress on blood glucose,blood fat,oxidative stress levels and to improve the blood circulation of the kidney in T2DM rats.更多还原