【摘要】 用甘氨酸模拟胶原,研究间苯二酚-噁唑烷E鞣性基质的形成以及与胶原之间的反应特性。通过核磁共振和激光粒度分析可知间苯二酚-噁唑烷E生成鞣性基质是通过噁唑烷E的C(5)和C(6)与间苯二酚的C(4)或C(6)连接而成,以2∶1或3∶2的摩尔比结合,以聚集态形式存在。鞣性基质与胶原之间的反应是噁唑烷E的羟甲基与胶原氨基形成了共价结合,间苯二酚的酚羟基与氨基发生了氢键结合。更多还原

【Abstract】 The Tanning Matrix can be formed by resorcinol and oxazolidine E,and the reactioncharateristics between Tanning Matrix and collagen were investigated through NMR and size distribution analysis.The collagen was simulated with glycin.The results showed that the molar combination ratio of Matrix as congeries between oxazolidine E and resorcinol was 2∶1 or 3∶2,the reaction positions were C(5) and C(6) of oxazolidine E and C(4) or C(6) of resorcinol.The hydroxymethyl of oxazolidine E bonded the amino group of collagen with covalent bond,and the phenol hydroxyl group of resorcinol combined the amino group of collagen with hydrogen bond.更多还原