【摘要】 目的观察2型糖尿病肾病(DN)患者24 h尿微量白蛋白(mALB)与血清高超敏C反应蛋白(hs-CRP)的变化及其临床意义。方法将120例2型糖尿病(DM)患者分为:单纯糖尿病组(DM组)40例、早期糖尿病肾病组(EDN组)40例、临床糖尿病肾病组(DN组)和40例健康体检者(正常对照组)40例。结果尿mALB在DN早期即可升高,且随病情发展而进一步升高(P<0.01);随着DM尿mALB增加,HbA1c水平逐渐增加(P<0.05);DM组血清Hs-CRP水平明显高于对照组,DN组又DM组,EDN组进一步升高(P<0.01);DN患者Hs-CRP水平升高与24h尿mALB排泄量呈正相关(r=0.59,P<0.05)。结论尿mALB和血清Hs-CRP作为两个独立的指标从不同方面反映2型DM患者肾功能的早期损害情况,是诊断2型DM早期肾损伤有价值的实验室指标,值得推广应用。更多还原

【Abstract】 Objective To observe 2 types of diabetic nephropathy(DN) in patients with 24h urinary albumin(mALB) and serum high sensitivity C-reactive protein(hs-CRP) and clinical significance of changes. Methods 120 patients with type 2 diabetes mellitus(DM) patients were divided into: simple diabetic group(DM),40 cases;② Early diabetic nephropathy(EDN),40 cases;③Clinical DN group(DN),40 cases and healthy(control group),40 cases.Results mALB urine in the early DN could be increased with the progression of the disease and further increased(P<0.01);With the DM urine mALB increased,HbA1c levels increased(P<0.05);DM Group serum Hs-CRP levels were significantly higher than control group,DM Group also higher than DM group and EDN group(P<0.01);DN patients Hs-CRP levels with the 24h urinary excretion mALB appeared positive correlation(r=0.59,P<0.05).Conclusions mALB urine and serum Hs-CRP as an indicator of two independent from the reflection of different aspects of type 2 DM patients with early renal damage,is the diagnosis of type 2 DM early kidney damage labs valuable indicators and should be applied.更多还原