【摘要】 目的:探讨吉西他滨、顺铂、泼尼松组成的GDP方案治疗复发难治性非霍奇金淋巴瘤的疗效和毒副反应。方法:GDP方案:吉西他滨1000mg/m2,加入生理盐水100mL中,静脉滴入(≥30min),d1、d8;DDP25mg/m2,静脉滴入,适当水化,d1～d3;PDN50mg/d,口服,d1～d10,21d为1个周期。全组32例患者接受1～6个周期化疗,平均2.7个周期。结果:27例患者完全缓解6例(22.22%),部分缓解11例(40.74%),总有效率62.96%。毒副反应主要为骨髓抑制,尤其血小板下降,Ⅲ～Ⅳ度血小板下降占全组29.63%。无治疗相关死亡。结论:GDP方案是治疗复发难治性非霍奇金淋巴瘤的一个有效方案,毒副反应可以耐受。更多还原

【Abstract】 OBJECTIVE:To study the effects and toxicity of gemcitabine combined with cisplatine and prednisone(GDP regimen)in the treatment of non-Hodgkin’s lymphoma(NHL).METHODS:Thirty-two patients with NHL were treated with gemcitabine,1 000 mg/m2,adding NS 100 mL,ivdrip(≥30 min),d1,d8;cisplatine,25 mg/m2,being hydrated,ivdrip,d1-d3;and prednisone,50 mg/d,po,d1-d10;Twenty-one days as one cycle.All patients received 1-6 cycles of the chemotherapy,and the average number of chemotherapy cycles was 2.7.RESLUTS:There were 6 cases of CR(22.22%),11 cases of PR(40.74%)and the total response rate was 62.96%.The most common toxicities were hematologic,especially thrombocytopenia.Grade Ⅲ or Ⅳ thrombocytopenia occurred in 29.63% of the patients.No treatment-related deaths occurred.CONCLUSION:GDP Regimen is an active regimen in recurrent or refractory non-Hodgkin lymphoma and can be administered with acceptable toxicity.更多还原