【摘要】 为了研究全程超分割放疗联合每周化疗治疗下咽癌的疗效,采用先行放疗同时每周化疗,DT50.4Gy后进行疗效评价,21例继续放化疗至总DT66～72Gy,25例行手术。放化疗组1、3年局控率、无瘤生存率和总生存率分别为76.2%、71.4%、76.2%及66.6%、57.1%、61.9%,手术组为76.0%、84.0%、80.0%及68.0%、72.0%、64.0%,两者差异无统计学意义,P>0.05。初步研究结果提示,对于不能手术的下咽癌全程超分割放疗联合每周化疗是一种有效的方法。更多还原

【Abstract】 The objective of this study was to evaluate the whole course hyper fractionation radiotherapy and concurrent chemotherapy weekly for hypopharyngeal carcinoma. A total of 25 patients received preoperative radiotherapy combined chemotherapy weekly followed by surgery(R+S group). A total of 21 patients received radiotherapy combined chemotherapy weekly(R group). All two groups completed their treatment course. Of R+S and R groups 1-,3-year survival rates were 80.0%,64.0% and 76.2%,61.9%. The 1-,3-year local control rates were 76.0%,68.0% and 76.2%,66.6%. The 1-,3-year disease free survival rates were 84.0%,72.0% and 71.4%,57.1%. There were no significant differences between the two groups(P>0.05). In conclusion,whole course hyper fractionation radiotherapy and concurrent chemotherapy weekly is a effective methods to hypopharyngeal carcinoma patient who can not receive surgery.更多还原