【摘要】 目的:探讨PET/CT在监测卵巢癌术后复发、转移中的应用价值。方法:回顾性分析20例卵巢癌术后患者全身18F-FDGPET/CT显像结果,临床随访时间6~18个月。确诊依据为手术病理检查、穿刺活检、多种影像学检查和临床随诊。结果:20例患者中,13例(65%)患者最终确定有复发或转移,PET/CT诊断复发转移病例的灵敏度为100.0%,特异性为85.7%、准确性为95.0%。13例患者病理或随访确诊32处病灶,PET/CT共发现29处阳性病灶。PET/CT诊断复发或转移灶的灵敏度、特异性、准确率、阳性预测值及阴性预测值分别为84.3%(27/32)、81.8%(9/11)、83.7%(36/43)、93.1%(27/29)和64.2%(9/14)。20例患者中,11例肿瘤标志CA125升高,10例PET/CT检查显示复发或转移病灶,并经最终结果证实,1例血清CA125水平升高但PET/CT未检出转移灶,至随访结束未发现复发或转移。另有3例血清CA125水平正常,但PET/CT检查发现转移灶。结论:18F-FDG PET/CT检查诊断卵巢癌术后复发转移灵敏度、特异性和准确率较高,在卵巢癌术后监测中有重要作用。更多还原

【Abstract】 OBJECTIVE: To evaluate the clinical value of PET/CT in detecting and diagnosing the recurrence and metastasis of ovarian carcinoma.METHODS: A retrospective study was done on 20 patients with ovarian cancer.The duration of follow-up was 6-18 months.The diagnosis of recurrence and metastasis was based on pathologic examination,multi-modality imaging and clinical follow-up.RESULTS:Thirteen(65%) of 20 patients had recurrence and metastasis.The sensitivity,specificity and accuracy of PET/CT in detecting recurrence and metastasis were 100.0%,85.7% and 95.0%,respectively.Thirty-two lesions were confirmed in 13 patients,and PET/CT imaging found 29 positive lesions.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of PET/CT in detecting recurrence and metastasis of all lesions were 84.3%(27/32),81.8%(9/11),83.7%(36/43),93.1%(27/29) and 64.2%(9/14)respectively.The serum carbohydrate antigen(CA)125 was increased in 11 patients,10 were confirmed recurrence of metastasis,the other 1 was closely follow up,but no sign of recurrence or metastasis was found.PET/CT detected recurrence and metastasis in 3 patients whose serum CA125 was normal.CONCLUSION: 18F-FDG PET/CT can detect the recurrence and metastasis of ovarian cancer with high sensitivity,specificity and accuracy and it has high value in monitoring and locating the recurrence of metastasis.更多还原