【摘要】 目的了解帕金森病伴抑郁障碍的临床特征。方法采用抑郁自评量表(SDS)、焦虑自评量表(SAS)、汉密尔顿抑郁量表24项版本(HAMD24)和汉密尔顿焦虑量表(HAMA)对确诊的35例帕金森病伴抑郁障碍患者(研究组)及35例抑郁症患者(对照组)进行评定及比较。结果两组患者SDS、HAMD24、HAMA总分间差异无统计学意义(P>0.05)。研究组患者SAS总分〔(55.9±11.6)分〕及HAMD24中体质量〔(0.6±0.4)分〕、认知障碍〔(3.9±1.7)分〕、昼夜变化〔(0.69±0.28)分〕因子分与对照组〔分别为(50.1±12.3)分、(1.2±0.4)分、(5.1±1.9)分和(1.32±0.39)分〕比较,差异均有统计学意义(t值分别为2.01、6.20、2.61和6.30,P<0.01)。结论帕金森病伴抑郁障碍具有独特的临床特征,即无明显的生物学症状,焦虑症状相对较多。更多还原

【Abstract】 Objective To study the clinical features of the depression in patients with Parkinson disease.Methods Clinical features were evaluated by the Hamilton Rating Scale for Depression(HAMD24),Hamilton Anxiety Scale(HAMA),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS)in 35 Parkinson patients with depression(research group)and 35 depression patients(control group).Results There was no significant difference in total scores of SDS,HAMD24,HAMA between 2 groups.Total scores of SAS was higher in research group than in control(P<0.05).The scores of cognitive function,diurnal variation were lower in research group than in control(P<0.01).Conclusion Depression of Parkinson patients shows special clinical features,with relative more anxiety symptom but without obvious biological.更多还原