【摘要】 目的探讨卵巢上皮癌组织中KAI1蛋白表达与其临床分期、转移及复发的关系。方法采用免疫组化(S-P)法检测45例卵巢上皮癌患者癌组织中KAI1蛋白的表达情况,并分析其与卵巢上皮癌的组织学类型、临床分期、组织学分级、转移及复发的关系。结果KAI1蛋白表达与患者的年龄无相关关系(P>0.05),与原发癌直径大小亦无相关关系(P>0.05);不同组织学类型的卵巢上皮癌KAI1蛋白表达情况间差异无统计学意义(P>0.05),组织学分级不同级别的卵巢上皮癌KAI1蛋白阳性、强阳性表达率间差异均无统计学意义(P>0.05);Ⅰ、Ⅱ期卵巢上皮癌KAI1蛋白表达情况与Ⅲ、Ⅳ期比较,差异有统计学意义(P<0.05),有无淋巴结转移和有无复发者KAI1蛋白阳性、强阳性表达率间差异均有统计学意义(P<0.05)。结论KAI1蛋白表达可能与卵巢上皮癌的临床分期、淋巴结转移及复发有一定关系,可作为估测肿瘤转移和预后的重要指标之一。更多还原

【Abstract】 Objective To detect the relationship of KAI1 expression in epithelial ovarian carcinoma(EOC) to its clinical stages,metastasis and prognosis.MethodsImmunohistochemistry was used to determine the KAI1 expression and its relationship to histological type and grading,clinical stage,metastasis and relapse in 45 EOC patients.ResultsThere was no relationship of KAI1 expression to patients′ ages,volume and histological types of EOC.The KAI1 expression,which was correlated with clinical staging,lymph node metastasis and recurrence,was higher in stage Ⅰ-Ⅱthan in stage Ⅲ-Ⅳ(P<0.01).KAI1 positive rate was higher in patients with negative lymph node than in those with positive(P<0.05),and higher in non-recurrent patients than in recurrent(P<0.01).There was significant difference in strong positive rate between patients with high histological grading and with low(P<0.05).ConclusionGene KAI1 is probably correlated to clinical staging,lymph node metastasis and relapse of EOC,and thus one of the important markers in determining neoplasm metastasis and prognosis.更多还原