【摘要】 目的观察隆起糜烂性胃炎患者血清白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)水平变化,以探讨其在隆起糜烂性胃炎发病中的可能免疫致病机制。方法采用双抗体夹心ELISA法测定60例隆起糜烂性胃炎患者IL-4、IFN-γ水平,并检测幽门螺杆菌(Hp)感染情况。结果隆起糜烂性胃炎患者Hp阳性组与Hp阴性组比较,血清IL-4水平明显升高,IFN-γ水平明显降低,差异均有统计学意义(t分别=2.23、2.16,P均<0.05);隆起糜烂性胃炎Hp阴性组血清IL-4、IFN-γ水平与慢性胃炎Hp阴性组比较,差异均无统计学意义(t分别=0.89、0.97,P均>0.05)。结论隆起糜烂性胃炎患者存在Th1/Th2细胞因子产生失衡,Th2免疫应答占优势。更多还原

【Abstract】 Objective To observe the change of serum levels of IL-4 and IFN-γ in patients with raised erosive gastritis for exploring the immunological pathogenesis of raised erosive gastritis.Method All patients were tested to determine whether infected with Hp and double-antibody sandwich ELISA was employed to determine the levels of serum IL-4 and IFN-γ in 60 cases of raised erosive gastritis.Results The level of serum IL-4 in Hp positive patients was higher than that in Hp negative patients,and the level of serum IFN-γ in Hp positive patients was lower than that in Hp negative patients.There were statistic differences between Hp positive patients and Hp negative patients(t =2.23,2.16,P<0.05).No significant difference of the serum levels of IL-4 and IFN-γ were found between Hp negative patients with raised erosive gastritis and Hp negative patients with chronic gastritis(t=0.89,0.97,P> 0.05).Conclusions There was an imbalance of cytokine production from Th1/Th2 cell in patients with raised erosive gastritis and the immune response of Th2 lymphocyte was preponderant.更多还原