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血管内超声弹性成像的一维径向应变计算

1-D radial strain analysis for intravascular ultrasound elastography

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【作者】 朱新建刘科邵金华白净张鹏飞张运苏海军

【Author】 ZHU Xinjian1,2,LIU Ke1,SHAO Jinhua1,BAI Jing1,ZHANG Pengfei3,ZHANG Yun3,SU Haijun4(1.Department of Biomedical Engineering,Tsinghua University,Beijing 100084,China;2.Fifth laboratory,Research Institute of Field Surgery,Daping Hospital,Third Military Medical University of Chinese PLA,State Key Laboratory for Trauma,Burn and Combined Injury,Chongqing 400042,China;3.Department of Cardiology,Qilu Hospital of Shandong University,Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education and Chinese Ministry of Health,Ji’nan 250012,China;4.School of Mathematics and System Science,Shandong University,Ji’nan 250100,China)

【机构】 清华大学生物医学工程系第三军医大学大坪医院野战外科研究所第五研究室,创伤,烧伤与复合伤国家重点实验室山东大学齐鲁医院心内科教育部和卫生部心血管重构与功能研究重点实验室山东大学数学与系统科学学院

【摘要】 为了进行血管内超声弹性成像(IVUSE)分析,开发了一种一维径向应变计算方法。该方法解决了探头与组织间相对旋转运动所引入的信号间相关性降低,以及在位移估计和血管壁的应变估计中高噪声、高误差的问题。用光流法和回归分析法,对血管壁的旋转运动进行定量估计和补偿;用一维互相关方法和Savitzky-Golay差分滤波器算法,计算IVUSE中位移和血管壁应变。用模拟数据进行了仿真。结果表明:该方法能在2.8°内实现旋转运动补偿,能区分出应变图内的血管壁、斑块以及外周组织。

【Abstract】 A 1-D radial strain calculational method was developed for intravascular ultrasound elastography(IVUSE) to overcome current problems,such as signal correlation reduction induced by catheter wiggling among neighboring tissue,noise and errors when estimating displacement or vessel wall strain.An optical flow algorithm and regression analysis were used to compensate for vessel wall rotation.A 1-D cross-correlation algorithm and the Savitzky-Golay difference filter algorithm were used to calculate the displacement and strain in IVUSE.Studies with simulated data show that the method can compensate for rotations 2.8 degrees and can distinguish between the vascular walls,plaques,and the surrounding tissues in the strain image.

【基金】 国家自然科学基金(60831003,30670577);清华-裕元基金;国家“九七三”重点基础研究项目(2006CB705700);国家“八六三”高技术项目(2006AA020803);博士点基金
  • 【文献出处】 清华大学学报(自然科学版) ,Journal of Tsinghua University(Science and Technology) , 编辑部邮箱 ,2009年12期
  • 【分类号】R310
  • 【被引频次】6
  • 【下载频次】254
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