【摘要】 目的探讨E-钙粘蛋白、环氧化酶2因子与前列腺癌病理分级及临床分期的关系。方法采用免疫组织化学SABC方法检测32例前列腺癌患者和24例良性前列腺增生标本中E-钙粘蛋白、环氧化酶2的表达。结果两组标本中E-钙粘蛋白在前列腺癌标本中的阳性表达率21.88%,在良性前列腺增生标本中的阳性表达率91.67%;而环氧化酶2在前列腺癌标本中的阳性表达率90.63%,在前列腺增生标本的阳性表达率37.50%。E-钙粘蛋白在高分化前列腺癌中的表达高于低分化前列腺癌;在A期和B期前列腺癌中的表达高于C期和D期的前列腺癌。环氧化酶2在低分化前列腺癌中的表达高于高分化前列腺癌;而在C期和D期的前列腺癌中的表达高于A期和B期前列腺癌。结论E-钙粘蛋白在前列腺癌标本中的表达明显低于前列腺增生标本,环氧化酶2的表达与此相反;两者在前列腺癌的表达与前列腺癌的病理分级及临床分期有关。更多还原

【Abstract】 Objective To investigate the expression of E-cadherin(E-cad) and cycloxygenase 2(COX-2)in the prostatic carcinoma(PCa)and analysis the ralationship of the two factors result and the pathologic grading,clinical stages of cancer.Methods Thirty-two paraffin sections of PCa patients and 24 paraffin sections of benign prostatic hyperplasia(BPH) patients had been chosen.Immunohistochemistry SABC method was employed to detect the expression of E-cad and COX-2 in all sections.Results The E-cad expression rates in PCa group is 21.88%,in BPH group is 91.67%.The COX-2 expression rates in PCa group is 90.63%,in BPH group is 37.50%.The E-cad expression rates on the clinical stage A and B PCa sections is obviously higher than those on stage C and D.Contrarily the COX-2 expression rates on the clinical stage A and B PCa sections is obviously lower than those on stage C and D.Conclusions The E-cad expression rates in PCa group are lower than BPH group and the COX-2 expression rates in PCa group are higher than BPH group.The expression rates of E-cad and COX-2 in PCa sections correlate with the pathologic grading of cancer and clinical stages.更多还原