【摘要】 目的:探讨结肠癌患者凝血与纤溶分子标志物的变化与肿瘤分期、分化程度及转移的关系。方法:结肠癌患者组125例,按Dukes分期分为A+B期组(58例)、C+D期组(67例);按分化程度分为低分化+未分化组(40例)、高分化+中分化组(85例)。正常对照组54例。取空腹外周静脉血,测定血浆组织因子(TF)、凝血酶-抗凝血酶Ⅲ复合物(TAT)、组织型纤溶酶原激活物(t-PA)、凝血酶原激活物抑制物(PAI-1)。结果:结肠癌患者组TF、TAT、t-PA、PAI-1水平较正常对照组明显增加(P<0.01)。C+D期组和低未分化组患者血浆TF、TAT、t-PA、PAI-1水平分别高于A+B期组和高中分化组(P<0.01)。结论:结肠癌患者存在明显的凝血及纤溶机制异常,且其变化与病情发展及预后有关,监测患者TF、TAT、t-PA、PAI-1水平可能成为预防血栓形成及慢性DIC等凝血性疾病的有效措施。更多还原

【Abstract】 Objective:To investigate the relationship between the changes of blood coagulation and fibrinolytic parameters with the pathological types,differentiation degree and metastasis in patients with colon cancer.Methods:By enzyme-linked immunosorben Assay(ELISA),4 plasma molecular markers of the coagulation and fibrinolysis systems were measured in 54 healthy volunteers and 125 cases of colon cancers,which included 58 Dukes A+B,67 Dukes C+D and 40 undifferentiated and poorly differentiated,85 well-differentiated and moderately differentiated patients.Their blood samples were taken from their peripheral veins.These molecular markers of coagulation and fibrinolytic system were as followings:tissue factor(TF),thrombin-antithrombin III complexes(TAT),tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1).Results:The levels of TF、TAT、t-PA、PAI-1 in 125 colon cancer patients were significantly higher than that in control group(P<0.01).The levels of TF、TAT、t-PA、PAI-1 increased progressively with the exacerbation and differentiation of colon cancer,and there was a significant difference between the two groups(P<0.01).Conclusion:The patients with colon cancer,especially those in the advanced stage usually,accompany with the dysfunction of blood coagulation,monitoring their alterations in TF、TAT、t-PA、PAI-1 levels could be a valid measure to prevent coagulation disorder and to direct the clinical use of anticoagulation drugs.更多还原