【摘要】 目的探讨血浆同型半胱氨酸(Hcy)水平与2型糖尿病患者颈动脉斑块形成的相关性。方法83例2型糖尿病患者,以高频超声确定患者颈动脉斑块的有无进行分组,对比2组间年龄、血浆Hcy、血脂、血压、腰围、体质量指数、糖化血红蛋白、果糖胺、尿酸、尿素氮、肌酐等的差异。采用Logistic分析方法确定2型糖尿病患者颈动脉发生斑块的危险因素。结果在斑块有和无2组间血浆Hcy水平存在差异,差异有统计学意义(P<0.01)。结论Hcy水平增高是2型糖尿病患者颈动脉发生斑块的独立危险因素。更多还原

【Abstract】 Objective To explore the relationship between plasma homocysteine(Hcy) level and carotid plaque in patients with type 2 diabetes mellitus(T2DM).Methods 83 patients with T2DM were recuited and their carotid plaque were measured by high resolved lined array transducer.At the same time their blood specimens were collected for determining the levels of Hcy,serum lipid,uric acid,serum creatinine,urea nitrogen,glycosylated hemoglobin(HbA1c),fructosamine(FA),and body mass index(BMI),blood pressure(BP),waist circumstance were assessed as well.To compare the difference of all the factors between two groups,multiple factors analysis was also made with logistic regression analysis.Results There were singnificant differences in Hcy between two groups(P<0.01).Conclusion The high level of plasma Hcy is the independent risk factor of carotid plaque in patients with T2DM.更多还原