【摘要】 目的探讨肝炎肝硬化患者血清内毒素(LPS)、肿瘤坏死因子-α(TNF-α)水平的检测意义。方法选择46例肝炎肝硬化患者,分为代偿组、失代偿组;22例轻度慢性肝炎患者作为对照组。采用鲎试验定量检测血浆LPS,双抗体夹心ELISA法检测TNF-α。结果对照组、肝硬化代偿组,失代偿组血清LPS与TNF-α依次明显升高。3组之间差异有统计学意义(P<0.01或P<0.05)。结论肝硬化失代偿期患者肠道内内毒素生成和吸收增多,其血清LPS、TNF-α生成和吸收增多,细菌易位的发生率增加,可促使病情进一步加重。更多还原

【Abstract】 Objective To study the significance of detecting the level of serum endotoxin and TNF-α in hepatitis and liver cirrhosis patients.Methods 46 patients including hepatitis and liver cirrhosis were divided into two groups-Compensation Group and discompensation Group;22 patients with mild chronic hepatitis as controls.Plasma LPS was quantitatively examined by Limulus test and TNF-α was detected by ELISA assay.Results Absorption and production of endotoxin increased in the intestinals of patients with discompensated cirrhosis.There was significant difference between 3 groups(P<0.01 or 0.05).Conclusion LPS and TNF-α generation and absorption increase in patients with discompensated cirrhosis and the incidence of bacterial translocation increases,which leads the illness to be further aggravated.更多还原