【摘要】 目的探讨TNF-α、IL-6与高血压肾损害发生发展之间的关系。方法将102例高血压患者根据其尿蛋白排泄率检测结果分为3组:单纯高血压组37例,高血压微量蛋白尿组36例,高血压临床蛋白尿组29例。采用放射免疫检测法检测血清TNF-α、IL-6水平。同期选择30例健康体检者作为正常血压对照组。结果高血压各组血清TNF-α、IL-6水平均高于正常血压对照组(P<0.05),随着尿蛋白排泄率的增加,TNF-α、IL-6水平呈上升趋势,组间比较差异有统计学意义(P<0.05)。高血压各组血清细胞因子水平与尿蛋白排泄率成正相关(r=0.51,P<0.01),而与血压水平无相关性。结论高血压肾损害患者血清TNF-α、IL-6水平明显升高,TNF-α、IL-6可能参与了高血压肾损害的发生和发展。更多还原

【Abstract】 Objective To investigate the changes of the serum levels of necrosis alpha(TNF-α)and interleukin 6(IL-6)in patients with hypertensive renal damage,whereby to try to study the correlation of TNF-αand IL-6 with the hypertensive renal damage.Methods 102 patients with primary hypertension were divided into three groups according to their urinary albumin excretion rate:normoalbuminuric hypertensive group(n=37),microalbuminuric hypertensive group(n=36)and proteinuric hypertensive group(n=29).Serum TNF-αand IL-6 were measured with radioimmune assay and 30 normotensive persons were selected as control group.Results Serum levels of TNF-αand IL-6 were significantly higher in patients with primary hypertension than those in normotensive control group(P<0.5).Serum levels of TNF-α and IL-6 showed the tendency of increase with the development of urinary albumin excretion.The significance was present among groups(P<0.05).TNF-αand IL-6 were found to have a positive correlation with urinary albumin excretion rate(r=0.79,P<0.01;r=0.75,P<0.01),but no correlation with the level of blood pressure.Conclusion serum TNF-αand IL-6 are remarkably increased in hypertensive patients and may play an important role in the pathogenesis and development of hypertensive renal damage.更多还原