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消疹止痒胶囊药效学研究

Pharmacodynamic Study of Xiaozhenzhiyang Capsule

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【作者】 寇琼白音夫牛兴东

【Author】 KOU Qiong1,BAI Yin-fu2,NIU Xing-dong 3 (1.Department of Traditional Chinese Medicine,Inner Mongolia Hospital,Huhhot 010017 China;2.Department of Drug lab,Institute of Inner Mongolia in the Mongolian,Huhhot 010010 China;3.Department of Digestive Center,The Mongolian Hospital of Inner Mongolia,Huhhot 010010 China)

【机构】 内蒙古自治区医院中医科内蒙古中蒙医研究所药物研究室内蒙古自治区中蒙医医院消化中心

【摘要】 目的:证实消疹止痒胶囊治疗过敏性皮炎、皮肤瘙痒症的疗效。方法:对消疹止痒胶囊进行药效学研究。结果:消疹止痒胶囊能提高豚鼠对组织胺的致痒阈值,可以抑制2,4-二硝基氯苯(DNCB)引发的小鼠皮肤迟发型过敏反应,能抑制二甲苯引发的小鼠耳廓急性炎症,能抑制血管通透性。结论:消疹止痒胶囊具有止痒、抗皮肤过敏反应、抗炎以及降低炎症反应作用。

【Abstract】 Objective:To confirm that Xiaozhenzhiyang capsule in the treatment of cutaneous pruritus caused by allergic dermatitis.Methods:Study on the pharmacodynamics of Xiaozhenzhiyang capsule.Results:Xiaozhenzhiyang capsule has function in increasing the response of itch-threshold of guinea pigs to histamine;Xiaozhenzhiyang capsule can inhibit delayed allergic reaction in mice skin caused by 2,4-dinitrochlorobenzene;In addition,it restrains xylene-induced acute mouse ear inflammation.What’s more,it has function in inhibiting vascular permeability.Conclusion: Xiaozhenzhiyang capsule has significant effects of antipruritic 、anti-skin allergies、anti-inflammatory and reduce inflammation.

【基金】 内蒙古科学技术厅科研项目(编号:21110214)
  • 【文献出处】 内蒙古医学杂志 ,Inner Mongolia Medical Journal , 编辑部邮箱 ,2009年10期
  • 【分类号】R285.5
  • 【下载频次】65
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