【摘要】 目的:探讨IGF-1和NF-κB在颈动脉粥样硬化(AS)斑块中的表达及分布于特点。方法:应用免疫组织化学技术测定15例人体颈AS斑块中IGF-1和NF-κB的表达。结果:AS斑块中IGF-1和NF-κB呈强阳性表达,且主要分布胞外基质中,偶见于泡沫细胞,胞核中NF-κB略有表达。而正常人动脉壁中IGF-1和NF-κB仅有微量表达。结论:检测颈AS斑块中NF-κB及其靶基因IGF-1的表达变化,可以看出其激活与AS病变的发生与发展密切相关,其在颈AS斑块形成过程中发挥重要作用。更多还原

【Abstract】 Objective:To investigate the expression and distribution of insulin like growth fatctor I(IGF-1) and nuclear factor-kappa B(NF-KB) in 15 atherosclerosis(AS) plaque of carotid artery cases.Methods:The protein level and area of IGF-1 and NF-KB in AS plaque and normal human artery were studied by means of immunohistochemistry.Results: The expression of IGF-1 and NF-KB had a high level in AS plaque and mainly located in extracellular matrix,and also documented in foam cells in AS plaque by chance.NF-KB was also slightly expressing in nucleus.In contrast the expression of IGF-1 was very low in normal arterial walls.Conclusion: The activation of NF-KB and its target gene IGF-1 are closely correlated in the forming and developing of AS,and the expressional changes of NF-KB,IGF-1 in the carotid AS plaque would play an important role in forming course.更多还原