【摘要】 男性不育病因复杂,其中弱精子症是导致男性不育的常见原因之一。然而,弱精子症的发病机制仍然不明确。近年来对弱精子症的研究取得了一定进展,一些基因(如tejin-2、DNAI1、DNAH5、DNAH11、AKAP4、SEPT4和Smcp)和蛋白(如精子蛋白ACTB、ANXA5、PRM1、PRM2、SABP等和精原蛋白Tf、PSA、PAP、Fractalkine等)被证实与弱精子症的发生有关,这些分子标记物的发现将为阐述弱精子症的分子机制提供基础,同时可能成为弱精子症诊断和治疗的靶标。更多还原

【Abstract】 One of the most common causes of male infertility is asthenospermia,whose pathogenesis,however,is not yet clear. Recent researches have found that some genes (such as tektin-2,DNAI1,DNAH5,DNAH11,AKAP4,SEPT4 and Smcp) and proteins (such as sperm proteins ACTB,ANXA5,PRM1,PRM2 and SABP and seminal proteins Tf,PSA,PAP and Fractalkine) are associated with asthenospermia. The finding of these molecular markers has provided a base for the explanation of the molecular mechanism of asthenospermia,and these markers may become the diagnostic and therapeutic targets of the disease.更多还原