【摘要】 Stra8(stimulated by retinoic acid gene 8)是哺乳动物生殖细胞由有丝分裂转变为减数分裂前特异表达的基因。Stra8在小鼠胚胎卵巢从前向后先后表达,从E12.5到E16.5持续约4d,Stra8表达后1d随之诱发减数分裂使减数分裂前期进行;在出生后睾丸开始Stra8的表达并诱发减数分裂,在胚胎性腺生殖细胞减数分裂的发生时间决定生殖细胞是朝雄性还是雌性的方向发育。视黄酸(retinoic acid,RA)的合成部位及CYP26b1的表达(降解RA的酶)调节Stra8基因表达。胞质Stra8蛋白增加导致生殖细胞进入减数分裂前期,但Stra8蛋白的功能还是未知的。更多还原

【Abstract】 Stra8 (stimulated by retinoic acid gene 8) is a specific expression gene in mammalian germ cells’ transition from mitosis to meiosis. Stra8 expresses in an anterior to posterior wave from embryonic days 12.5 to 16.5 in germ cells of XX gonads in mice. Meiosis germ cells are observed 1 day after Stra8 expression, which begins in the testis after birth and triggers meiosis entry. Germ cell sex determination is directed by a difference in the timing of entry into meiosis in embryonic gonads. The position of retinoic acid production and CYP26b1 expression that metabolizes RA to an inactive form regulates Stra8 expression. Although cytoplasmic protein Stra8 is necessary for the entry of germ cells into meiotic prophase, the function of the protein remains unknown.更多还原