【摘要】 目的:探讨急诊经皮冠状动脉介入治疗(PCI)中使用国产替罗非班(欣维宁)对患者的远期心功能影响。方法:回顾性分析急诊PCI治疗患者117例,按是否使用国产替罗非班分为治疗组(36例)和对照组(81例),随访1年,观察左室射血分数(LVEF)、左室舒张末期容积指数(LVEDVI)、左室收缩末期容积指数(LVESVI)。结果:两组一般情况、基础临床情况和造影、介入资料均无显著差异(P>0.05),且术后即刻TI MI3级血流获得两组相似(94.44%vs92.59%,P>0.05)。术后随访1月时,两组左室射血分数均较术前有明显改善,但治疗组改善更明显(47.89%vs41.75%,P<0.05);且治疗组左室舒张末期容积指数(73.49ml/m2vs82.77ml/m2,P<0.05)和收缩末期容积指数(42.86ml/m2vs53.52ml/m2,P<0.05)均较对照组明显下降。随访1年,两组心功能相比未见显著差异,但两组心功能较术后1月有明显改善。结论:急诊PCI术中使用国产替罗非班能明显改善患者PCI术后1月的心功能,而1年后这种获益不复存在。更多还原

【Abstract】 Objective: To investigate the remote effect of home-made tirofiban on cardiac function of patients undergone emergency percutaneous coronary intervention(PCI).Methods:One hundred and seventeen patients underwent emergency PCI were divided into two groups: tirofiban treatment group(n=36) and the control group(n=81).Left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI) were assessed 1 year after PCI.Results: There were no significant differences between two groups in basic clinical or angiographic characteristics before PCI(P>0.05).The two groups had no difference in percentage of TIMI 3 flow achieved in IRAs after PCI(94.44% vs 92.59%,P>0.05).LEVF significantly improved at 1-month follow up in two groups,but it improved more pronounced in tirofiban treatment group(47.89% vs 41.75%,P<0.05).LVEDVI and LVSDVI were decreased significantly than those in control group(73.49 ml/m2 vs 82.77 ml/m2,P<0.05;42.86 ml/m2 vs 53.52 ml/m2,P<0.05).There was no significant difference between two groups on improvement of cardiac function at one year following,but heart function was dramatically improved compared with that at 1-month after PCI in both groups.Conclusions: Application of China-made tirofiban during emergency PCI in patients with acute myocardial infarction could improve heart function at 1 month after PCI,but this superiority can not maintain 1 year after PCI.更多还原