【摘要】 目的:探讨在急性心肌梗死(AMI)院前急救中预防性应用胺碘酮对恶性心律失常的发生、除颤使用率的影响及安全性。方法:采用前瞻性随机对照原则,将院前急救过程中诊断ST段抬高型AMI的患者94例,分为预防性应用胺碘酮实施组和常规治疗组,统计恶性心律失常、除颤、死亡、不良反应例数。结果:实施组43例,对照组51例。恶性心律失常发生率分别为21%和90%(P<0.01);除颤使用率分别为9.3%和23.5%(P<0.01);死亡率分别为2.3%和5.9%(P<0.05);实施组不良反应9例。结论:在AMI院前急救中,预防性应用胺碘酮可显著降低恶性心律失常发生率,减少除颤的使用率,增加抢救成功率,无严重不良反应。更多还原

【Abstract】 Objective:To explore the effect of prophylactic application of amiodarone on malignant arrhythmia in pre-hospital care for treatment of acute myocardial infarction(AMI) and its safety.Methods:Ninety-four patients diagnosed as ST elevated AMI in pre-hospital care were divided into two groups:Amiodarone prophylactic application group and routine treatment group.Cases of malignant arrhythmia,reversion of fibrillation,death and adverse reaction were statistically analyzed.Results:The rate of malignant arrhythmia were 21% in amiodarone prophylactic application group and 90% in routine treatment group(P<0.01).The rate of reversion of fibrillation were 9.3% in amiodarone prophylactic application group and 23.5% in routine treatment group(P<0.01).The death rate were 2.3% in amiodarone prophylactic application group and 5.9% in routine treatment group(P<0.05).Adverse reactions were observed in 9 cases in amiodarone prophylactic application group.Conclusions:Prophylactic application of amiodarone can significantly decrease the incidence of malignant arrhythmia,decrease the utilization rate of defibrillator,increase the rate of successful rescue,and with no severe adverse reaction.更多还原