【摘要】 精原干细胞(spermatogonial stem cells,SSCs)是雄性哺乳动物体内的一种成体干细胞,在睾丸微环境中既具有自我更新潜能,又具有定向分化潜能,是自然状态下出生后,动物体内在整个生命期间进行自我更新并能将基因传递至子代的唯一成体干细胞。精原干细胞在建立转基因动物中具有重要的应用价值,现已成为转基因研究领域的热点之一。介绍了精原干细胞的来源、形成、类型及分化,同时对其在转基因动物研究中的应用做一综述。更多还原

【Abstract】 Spermatogonial stem cells(SSCs) are kinds of adult stem cells in male mammalia.They are not only the ones capable of self-renewing and differentiating in testis niche,but also the only ones in normal postnatal body that undergo self-renewal throughout life and transmit gene to offspring.SSCs have significant value in producing transgenic animals.The origin,formation,type and differentiation of SSCs were reviewed.The application of SSCs in transgenic animals was also summarized.更多还原